Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

The follicular variant of papillary thyroid carcinoma usually presents as a tumor packaged and less common as infiltrative neoplasms partial / non-encapsulated. The shape is packed rarely metastasize to the lymph nodes, whereas infiltrative tumor often harbor nodal metastasis. Profile follicular variant molecules are shown to be close to the group adenoma / carcinoma follicular tumors with high RAS and BRAF mutation rate is very low.

A comprehensive survey of oncogenic mutation in the follicular variant of papillary thyroid carcinoma in accordance with the shape of encapsulated and infiltrative not done. paraffin tissue from 28 patients with packaged and 19 with the follicular variant of infiltrating into the target mass spectrometry genotyping include the most significant oncogenes in thyroid carcinoma: 111 mutations in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, AKT1 and other related genes. There were no differences in age, gender, tumor size and angioinvasion between encapsulation or infiltrative tumor. infiltrative carcinomas have a higher frequency of extrathyroid extension, positive margins and nodal metastases from encapsulated tumor (P <0.05). The BRAF 1799T> A mutation was found in 5 of 19 (26%) of tumor infiltrating and none of the encapsulated carcinoma (P = 0.007).

Instead, RAS mutations were observed in 10 of 28 (36%) of the encapsulated group (5 NRAS_Q61R, 3 HRAS_Q61, 1 HRAS_G13C and 1 KRAS_Q61R) and only 2 of 19 (10%) of the infiltrative tumors (P = 0.09). One carcinoma packed show PAX8 / PPARgamma rearrangements, whereas infiltrative tumor harbored two RET / PTC fusion. Packed follicular variant of papillary thyroid carcinoma had a molecular profile is very close to the follicular adenoma / carcinoma (high level RAS and BRAF mutation). Infiltrative follicular variant had the opposite molecular profile closer to classical papillary thyroid carcinoma than follicular adenoma / carcinoma (BRAF> RAS mutation). Profile molecule is packaged and infiltrative follicular variant align their biological behavior (ie, nodal metastatic and invasive pattern).

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

molecular heterozygous genotype showed ataxia-telangiectasia tend to breast cancer.

Approximately 1.4% of the general population are heterozygous carriers of the gene for ataxiatelangiectasia (A-T), an autosomal recessive progressive neurological syndromes in which cancer incidence homozygotes was about 100 times that of the general population’s level. The hypothesis that A-T heterozygotes tend to breast cancer tested with robust statistical method contains an index-based genotyping test molecule. A-T gene carrier status of 775 blood relatives in the family 99 A-T is determined by tracing the A-T gene in each family through flanking DNA markers closely linked.

There were 33 women with breast cancer that can genotype; 25 of them A-T heterozygotes, compared with the expected (odds ratio 3.8, 95% confidence limits from 1.7 to 8.4, one-sided p = 0.0001) 14.9. This suggests that the gene heterozygous A-T predisposition to breast cancer. For 21-onset breast cancer before age 60, the odds ratio was 2.9 (1.1 to 7.6, p = 0.009) and for 12 cases with onset at age 60 or older, the odds ratio was 6.4 (1 , 4 to 28.8, p = 0.002).

Bovine Fallopian Tube Total RNA*

BR-410 0.05mg
EUR 235

Bovine Fallopian Tube Total Protein*

BT-410 0.5mg
EUR 153

Normal Human Fallopian tube (5 slides/pack, single section/slide)

S-HuFPT121 1 unit
EUR 95

Normal Human Fallopian tube (single section per slide) (5 slides/pack)

HuFPT121 5 slides
EUR 150

Cynomolgus Monkey: Fallopian tube (5 slides/pack, single section/slide)

S-CyFPT201 1 unit
EUR 95

Innovative Grade US Origin Bovine Fallopian Tube

IGBOFALF each
EUR 210
Description: Innovative Grade US Origin Bovine Fallopian Tube

Innovative Grade US Origin Bovine Fallopian Tube

IGBOFALP each
EUR 210
Description: Innovative Grade US Origin Bovine Fallopian Tube

Innovative Grade US Origin Bovine Fallopian Tube

IGBOFALS each
EUR 210
Description: Innovative Grade US Origin Bovine Fallopian Tube

Innovative Grade US Origin Bovine Fallopian Tube

IGBOFALZ each
EUR 133
Description: Innovative Grade US Origin Bovine Fallopian Tube

Bovine Skin Frozen Sections

BF-101 10 slides
EUR 261

Bovine Lung Frozen Sections

BF-601 10 slides
EUR 261

Bovine Colon Frozen Sections

BF-311 10 slides
EUR 261

Bovine Liver Frozen Sections

BF-314 10 slides
EUR 261

Bovine Ovary Frozen Sections

BF-406 10 slides
EUR 261

Bovine Heart Frozen Sections

BF-801 10 slides
EUR 261

Bovine Aorta Frozen Sections

BF-807 10 slides
EUR 261

Bovine Testis Frozen Sections

BF-401 10 slides
EUR 261

Bovine Uterus Frozen Sections

BF-411 10 slides
EUR 261

Bovine Pineal Frozen Sections

BF-505 10 slides
EUR 261

Bovine Spleen Frozen Sections

BF-701 10 slides
EUR 261

Bovine Thymus Frozen Sections

BF-702 10 slides
EUR 261

Bovine Kidney Frozen Sections

BF-901 10 slides
EUR 261

Bovine Stomach Frozen Sections

BF-302 10 slides
EUR 261

Bovine Thyroid Frozen Sections

BF-503 10 slides
EUR 261

Bovine Bladder Frozen Sections

BF-902 10 slides
EUR 261

Bovine Pancreas Frozen Sections

BF-313 10 slides
EUR 261

Bovine Prostate Frozen Sections

BF-408 10 slides
EUR 261

Bovine Placenta Frozen Sections

BF-413 10 slides
EUR 261

Bovine Brainstem Frozen Sections

BF-215 10 slides
EUR 261

Bovine Esophagus Frozen Sections

BF-301 10 slides
EUR 261

Bovine Pituitary Frozen Sections

BF-502 10 slides
EUR 261

Bovine Epididymis Frozen Sections

BF-402 10 slides
EUR 261

Fallopian tube disease spectrum (fallopian tube cancer progression) tissue array

UTE601 each
EUR 306
Description: Fallopian tube disease spectrum (fallopian tube cancer progression) tissue array, including pathology grade, TNM and clinical stage, 30 cases/60 cores

Bovine Lymph Nodes Frozen Sections

BF-703 10 slides
EUR 261

Bovine Brain, Thalamus Frozen Sections

BF-205 10 slides
EUR 261

Bovine Brain, Striatum Frozen Sections

BF-214 10 slides
EUR 261

Bovine Skeletal Muscles Frozen Sections

BF-102 10 slides
EUR 261

Bovine Brain, Cerebellum Frozen Sections

BF-202 10 slides
EUR 261

Bovine Salivary, Parotid Frozen Sections

BF-316 10 slides
EUR 261

Bovine Brain, Hippocampus Frozen Sections

BF-203 10 slides
EUR 261

Bovine Brain, Hypothalamus Frozen Sections

BF-204 10 slides
EUR 261

Bovine Salivary, Submaxillary Frozen Sections

BF-317 10 slides
EUR 261

Bovine Brain, Cerebral Cortex Frozen Sections

BF-210 10 slides
EUR 261

Bovine Brain, Caudate Nucleus Frozen Sections

BF-242 10 slides
EUR 261

Bovine Brain, Choroids Plexus Frozen Sections

BF-243 10 slides
EUR 261

Bovine Small Intestine, Ileum Frozen Sections

BF-309 10 slides
EUR 261

Human Fallopian Tube Tissue Lysate

IHUFALTL100UG each
EUR 1413
Description: Human Fallopian Tube Tissue Lysate

Human Fallopian Tube Tissue Lysate

MBS8411365-01mg 0.1mg
EUR 1810

Human Fallopian Tube Tissue Lysate

MBS8411365-5x01mg 5x0.1mg
EUR 7965

Bovine Small Intestine, Jejunum Frozen Sections

BF-308 10 slides
EUR 261

Bovine Small Intestine, Duodenum Frozen Sections

BF-307 10 slides
EUR 261

Human Fallopian Tube Epithelial Cells

ABC-TC5521 1 vial Ask for price
Description: Fallopian Tube Epithelial Cells have been isolated, plated and expanded in culture vessels three times before being harvested for cryopreservation to ensure the highest viability and plating efficiency. Fallopian Tube Cells are quality tested in our Medium to ensure optimal morphology and growth over a period of at least 5 population doublings.

Human Fallopian Tube Secretory Epithelial Cells

cAP-0215 1Frozen Vial
EUR 643.5

OCPB00187-100UG - Fallopian Tube Lysate

OCPB00187-100UG 0.1mg
EUR 809

Urogenital Tissue Slide (Fallopian Tube-Normal)

11-901-10um 10 um
EUR 241.8

Urogenital Tissue Slide (Fallopian Tube-Normal)

11-901-4um 4 um
EUR 216.6

Urogenital Tissue Slide (Fallopian Tube-Benign)

11-903-10um 10 um
EUR 241.8

Urogenital Tissue Slide (Fallopian Tube-Benign)

11-903-4um 4 um
EUR 216.6

Urogenital Tissue Slide (Fallopian Tube-Benign)

MBS154258-10um 10um
EUR 210

Urogenital Tissue Slide (Fallopian Tube-Benign)

MBS154258-4um 4um
EUR 195

Urogenital Tissue Slide (Fallopian Tube-Benign)

MBS154258-5x10um 5x10um
EUR 920

Urogenital Tissue Slide (Fallopian Tube-Normal)

MBS154285-10um 10um
EUR 210

Urogenital Tissue Slide (Fallopian Tube-Normal)

MBS154285-4um 4um
EUR 195

Urogenital Tissue Slide (Fallopian Tube-Normal)

MBS154285-5x10um 5x10um
EUR 920

Urogenital Tissue Slide (Fallopian Tube-Abnormal)

11-905-10um 10 um
EUR 241.8

Urogenital Tissue Slide (Fallopian Tube-Abnormal)

11-905-4um 4 um
EUR 216.6

Urogenital Tissue Slide (Fallopian Tube-Abnormal)

MBS154302-10um 10um
EUR 210

Urogenital Tissue Slide (Fallopian Tube-Abnormal)

MBS154302-4um 4um
EUR 195

Urogenital Tissue Slide (Fallopian Tube-Abnormal)

MBS154302-5x10um 5x10um
EUR 920

cDNA - Human Adult Normal Tissue: Fallopian Tube

C1234115-10 10 reactions
EUR 237

Immortalized Human Fallopian Tube Secretory Epithelial Cells

CSC-I9204L One Frozen vial Ask for price

cDNA - Monkey (Rhesus) Normal Tissue: Fallopian Tube

C1534115 40 reactions
EUR 723

Innovative Grade US Origin Porcine Fallopian Tube

IGPCFALF each
EUR 133
Description: Innovative Grade US Origin Porcine Fallopian Tube

Innovative Grade US Origin Porcine Fallopian Tube

IGPCFALP each
EUR 210
Description: Innovative Grade US Origin Porcine Fallopian Tube

Innovative Grade US Origin Porcine Fallopian Tube

IGPCFALS each
EUR 210
Description: Innovative Grade US Origin Porcine Fallopian Tube

Innovative Grade US Origin Porcine Fallopian Tube

IGPCFALZ each
EUR 133
Description: Innovative Grade US Origin Porcine Fallopian Tube

Bovine Tissue Frozen Sections Panel, Set of any 10 tissues

BF-010 10X4 slides
EUR 1085

Immortalized Human Fallopian Tube Secretory Epithelial Cells (FT240)

T0762 1x10^6 cells / 1.0 ml
EUR 2750

Total Protein - Human Adult Normal Tissue: Fallopian Tube

P1234115 1 mg
EUR 590

Tissue, Total Protein, Human Adult Normal, Fallopian Tube

MBS656983-1mg 1mg
EUR 860

Tissue, Total Protein, Human Adult Normal, Fallopian Tube

MBS656983-5x1mg 5x1mg
EUR 3640

Human Urogenital Tissue Slide (Fallopian Tube normal) (5 slides/pk)

HTS-11901 1 pk
EUR 343.2

Human Urogenital Tissue Slide (Fallopian Tube Benign) (5 slides/pk)

HTS-11903 1 pk
EUR 343.2

Immortalized Human Fallopian Tube Secretory Epithelial Cells (FT33-shp53-R24C)

T0609 1x10^6 cells / 1.0 ml
EUR 3700

Human Urogenital Tissue Slide (Fallopian Tube Abnormal) (5 slides/pk)

HTS-11905 1 pk
EUR 343.2

Rat Eye Frozen Sections

RF-106 10 slides
EUR 266

Tissue cDNA, First Strand, Human Adult Normal, Fallopian Tube, BioGenomics

MBS652556-10Tests 10Tests
EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Fallopian Tube, BioGenomics

MBS652556-5x10Tests 5x10Tests
EUR 2215

Dog Skin Frozen Sections

DF-101 10 slides
EUR 261

Dog Lung Frozen Sections

DF-601 10 slides
EUR 261

Cat Lung Frozen Sections

FF-601 10 slides
EUR 261

Pig Skin Frozen Sections

PF-101 10 slides
EUR 261

Pig Lung Frozen Sections

PF-601 10 slides
EUR 261

Rat Skin Frozen Sections

RF-101 10 slides
EUR 228

Rat Lung Frozen Sections

RF-601 10 slides
EUR 228

Dog Liver Frozen Sections

DF-314 10 slides
EUR 261

Dog Ovary Frozen Sections

DF-406 10 slides
EUR 261

Dog Heart Frozen Sections

DF-801 10 slides
EUR 261

Cat Liver Frozen Sections

FF-314 10 slides
EUR 261

Cat Ovary Frozen Sections

FF-406 10 slides
EUR 261

Cat Heart Frozen Sections

FF-801 10 slides
EUR 261

Pig Colon Frozen Sections

PF-211 10 slides
EUR 261

Pig Liver Frozen Sections

PF-314 10 slides
EUR 261

Pig Ovary Frozen Sections

PF-406 10 slides
EUR 261

Pig Heart Frozen Sections

PF-801 10 slides
EUR 261

Pig Aorta Frozen Sections

PF-807 10 slides
EUR 261

Rat Cecum Frozen Sections

RF-310 10 slides
EUR 228

Rat Colon Frozen Sections

RF-311 10 slides
EUR 228

Rat Liver Frozen Sections

RF-314 10 slides
EUR 228

Rat Ovary Frozen Sections

RF-406 10 slides
EUR 228

Rat Penis Frozen Sections

RF-416 10 slides
EUR 228

Rat Aorta Frozen Sections

RF-807 10 slides
EUR 266

Dog Tongue Frozen Sections

DF-105 10 slides
EUR 261

Dog Rectum Frozen Sections

DF-312 10 slides
EUR 261

Dog Testis Frozen Sections

DF-401 10 slides
EUR 261

Dog Spleen Frozen Sections

DF-701 10 slides
EUR 261

Dog Thymus Frozen Sections

DF-702 10 slides
EUR 261

Dog Kidney Frozen Sections

DF-901 10 slides
EUR 261

Cat Tongue Frozen Sections

FF-105 10 slides
EUR 261

Cat Rectum Frozen Sections

FF-312 10 slides
EUR 261

Cat Testis Frozen Sections

FF-401 10 slides
EUR 261

Cat Spleen Frozen Sections

FF-701 10 slides
EUR 261

Cat Thymus Frozen Sections

FF-702 10 slides
EUR 261

Cat Kidney Frozen Sections

FF-901 10 slides
EUR 261

Human Skin Frozen Sections

HF-101 10slides
EUR 240

Human Lung Frozen Sections

HF-601 10slides
EUR 240

Human Vein Frozen Sections

HF-821 10slides
EUR 240

Pig Testis Frozen Sections

PF-401 10 slides
EUR 261

Pig Uterus Frozen Sections

PF-411 10 slides
EUR 261

Pig Pineal Frozen Sections

PF-505 10 slides
EUR 261

Pig Spleen Frozen Sections

PF-701 10 slides
EUR 261

Pig Thymus Frozen Sections

PF-702 10 slides
EUR 261

Pig Kidney Frozen Sections

PF-901 10 slides
EUR 261

Rat Tongue Frozen Sections

RF-105 10 slides
EUR 266

Rat Rectum Frozen Sections

RF-312 10 slides
EUR 228

Rat Testis Frozen Sections

RF-401 10 slides
EUR 228

Rat Vagina Frozen Sections

RF-412 10 slides
EUR 228

Rat Spleen Frozen Sections

RF-701 10 slides
EUR 228

Rat Thymus Frozen Sections

RF-702 10 slides
EUR 228

Rat Kidney Frozen Sections

RF-901 10 slides
EUR 228

Sheep Skin Frozen Sections

SF-101 10 slides
EUR 261

Sheep Lung Frozen Sections

SF-601 10 slides
EUR 261

Equine Skin Frozen Sections

EF-101 10 slides
EUR 261

Equine Lung Frozen Sections

EF-601 10 slides
EUR 261

Dog Stomach Frozen Sections

DF-302 10 slides
EUR 261

Thus the risk of breast cancer for women heterozygous A-T is not limited to young women, but appears higher in old age. Of all breast cancers in the United States, 6.6% can occur in women who are A-T heterozygotes. This proportion was some great times from the approximate proportion of BRCA1 mutation carriers in breast cancer cases with onset at any age.

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