Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

The follicular variant of papillary thyroid carcinoma usually presents as a tumor packaged and less common as infiltrative neoplasms partial / non-encapsulated. The shape is packed rarely metastasize to the lymph nodes, whereas infiltrative tumor often harbor nodal metastasis. Profile follicular variant molecules are shown to be close to the group adenoma / carcinoma follicular tumors with high RAS and BRAF mutation rate is very low.

A comprehensive survey of oncogenic mutation in the follicular variant of papillary thyroid carcinoma in accordance with the shape of encapsulated and infiltrative not done. paraffin tissue from 28 patients with packaged and 19 with the follicular variant of infiltrating into the target mass spectrometry genotyping include the most significant oncogenes in thyroid carcinoma: 111 mutations in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, AKT1 and other related genes. There were no differences in age, gender, tumor size and angioinvasion between encapsulation or infiltrative tumor. infiltrative carcinomas have a higher frequency of extrathyroid extension, positive margins and nodal metastases from encapsulated tumor (P <0.05). The BRAF 1799T> A mutation was found in 5 of 19 (26%) of tumor infiltrating and none of the encapsulated carcinoma (P = 0.007).

Instead, RAS mutations were observed in 10 of 28 (36%) of the encapsulated group (5 NRAS_Q61R, 3 HRAS_Q61, 1 HRAS_G13C and 1 KRAS_Q61R) and only 2 of 19 (10%) of the infiltrative tumors (P = 0.09). One carcinoma packed show PAX8 / PPARgamma rearrangements, whereas infiltrative tumor harbored two RET / PTC fusion. Packed follicular variant of papillary thyroid carcinoma had a molecular profile is very close to the follicular adenoma / carcinoma (high level RAS and BRAF mutation). Infiltrative follicular variant had the opposite molecular profile closer to classical papillary thyroid carcinoma than follicular adenoma / carcinoma (BRAF> RAS mutation). Profile molecule is packaged and infiltrative follicular variant align their biological behavior (ie, nodal metastatic and invasive pattern).

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

molecular heterozygous genotype showed ataxia-telangiectasia tend to breast cancer.

Approximately 1.4% of the general population are heterozygous carriers of the gene for ataxiatelangiectasia (A-T), an autosomal recessive progressive neurological syndromes in which cancer incidence homozygotes was about 100 times that of the general population’s level. The hypothesis that A-T heterozygotes tend to breast cancer tested with robust statistical method contains an index-based genotyping test molecule. A-T gene carrier status of 775 blood relatives in the family 99 A-T is determined by tracing the A-T gene in each family through flanking DNA markers closely linked.

There were 33 women with breast cancer that can genotype; 25 of them A-T heterozygotes, compared with the expected (odds ratio 3.8, 95% confidence limits from 1.7 to 8.4, one-sided p = 0.0001) 14.9. This suggests that the gene heterozygous A-T predisposition to breast cancer. For 21-onset breast cancer before age 60, the odds ratio was 2.9 (1.1 to 7.6, p = 0.009) and for 12 cases with onset at age 60 or older, the odds ratio was 6.4 (1 , 4 to 28.8, p = 0.002).

Urogenital Tissue Slide (Fallopian Tube-Benign)

11-903-4um 4 um
EUR 180.5

Urogenital Tissue Slide (Fallopian Tube-Abnormal)

11-905-10um 10 um
EUR 201.5

Urogenital Tissue Slide (Fallopian Tube-Abnormal)

11-905-4um 4 um
EUR 180.5

Control sections for FD NeuroApop™ Kit (frozen)

PCS102- each
EUR 73

Control sections for FD NeuroApop™ Kit (frozen)

PCS102-2 each
EUR 67.12
Description: Best quality products

cDNA from Human Adult Normal Tissue: Fallopian Tube

C1234115-10 10 reactions
EUR 231
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Fallopian Tube

C1534115 40 reactions
EUR 540
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total Protein from Human Adult Normal Tissue: Fallopian Tube

P1234115 1 mg
EUR 497
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Human Urogenital Tissue Slide (Fallopian Tube normal) (5 slides/pk)

HTS-11901 1 pk
EUR 286

Human Urogenital Tissue Slide (Fallopian Tube Benign) (5 slides/pk)

HTS-11903 1 pk
EUR 286

Human Urogenital Tissue Slide (Fallopian Tube Abnormal) (5 slides/pk)

HTS-11905 1 pk
EUR 286

Control Sections for FD NeuroSilver™ Kit

PCS101 each
EUR 58

Fine natural hair brush for mounting sections

PO501 each
EUR 67

CancerSeq? Plus Paraffin Tissue Tumor Sections: Breast

T2235086-SC 5 curls
EUR 932
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

CancerSeq? Plus Paraffin Tissue Tumor Sections: Stomach

T2235248-SC 5 curls
EUR 932
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

CancerSeq? Plus Paraffin Tissue Tumor Sections: Thyroid

T2235265-SC 5 curls
EUR 932
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Drain tube

2393092 8unit
EUR 275

Tube Rack

BV1010-05 1 PC
EUR 94.58

Tube Rack

BV1010-12 1 PC
EUR 94.58

Tube Rack

BV1010-13 1 PC
EUR 94.58

Tube Rack

BV1010-150 1 PC
EUR 94.58

Tube Rack

BV1010-1520 1 PC
EUR 94.58

Tube Rack

BV1010-25 1 PC
EUR 178.97

Tube Rack

BV1010-500 1 PC
EUR 94.58

Centrifuge Tube

C1005-T5*-Clear 1 PC
EUR 97.63

Tube Adapter

C2000-A02 1 PC
EUR 204.56

Tube holder

R2020-0507 1 PC
EUR 110.46

Tube holder

R2020-150 1 PC
EUR 101.69

Tube holder

R2020-1520 1 PC
EUR 110.46

Tube holder

R2020-500 1 PC
EUR 118.43

Tube holder

R2020-PCR 1 PC
EUR 134.38

Control sections for FD NeuroApop™ Kit (paraffin)

PCS102-1 each
EUR 67.03
Description: Best quality products

FD NeuroSilver™ Kit II (for 300 sections)

PK301 kit
EUR 792

FD NeuroSilver™ Kit II (for 150 sections)

PK301A kit
EUR 658

Digital Tube Roller

abx725018-1Unitwith10Rollers 1 Unit with 10 Rollers
EUR 815

Digital Tube Roller

abx725018-1Unitwith4Rollers 1 Unit with 4 Rollers
EUR 432

Digital Tube Roller

abx725018-1Unitwith6Rollers 1 Unit with 6 Rollers
EUR 746

Sterile Centrifuge Tube

C1005-T5-ST 1 PC
EUR 83.13

5ml Tube holder

D2400-R5 1 PC
EUR 742.73

mini tube gel insert

EVS1100-TUBEINSERT ea
EUR 411

maxi tube gel insert

EVS1300-TUBEINSERT ea
EUR 504

PIPET CONTROLLER SILICONE TUBE

357483 1/pk
EUR 43
Description: Falcon Liquid Handling Equipment; Falcon Pipet Controllers and Accessories

Tubulin Epsilon (TUBe) Antibody

20-abx128096
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Tubulin Epsilon (TUBe) Antibody

20-abx101415
  • EUR 439.00
  • EUR 133.00
  • EUR 1233.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Microcentrifuge Tube 1.5mL (Axygen)

TUBE1.5AX-S 500box
EUR 213
Description: Screw-cap tubes, 1.5 mL, Axygen brand, with caps for use in microcentrifuge style Bullet Blenders with a "W" in the serial number. Sterile, RNase & DNase free.

wl tube 6 w

VLT6-WL ea
EUR 73

wl tube 8 w

VLT8-WL ea
EUR 73

Tube Holder Set (Small

MSS-1100 mL
EUR 147
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Recombinant Tubulin Epsilon (TUBe)

4-RPE719Hu01
  • EUR 485.28
  • EUR 233.00
  • EUR 1544.80
  • EUR 581.60
  • EUR 1063.20
  • EUR 388.00
  • EUR 3712.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Tubulin Epsilon expressed in: E.coli

Recombinant Tubulin Epsilon (TUBe)

4-RPE719Mu01
  • EUR 503.20
  • EUR 238.00
  • EUR 1612.00
  • EUR 604.00
  • EUR 1108.00
  • EUR 400.00
  • EUR 3880.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Tubulin Epsilon expressed in: E.coli

Angiogenesis (Tube Formation) Assay

K905-50
EUR 479

Frozen Tissue Section - Lupus: Adrenal

T1236004Lup 5 slides
EUR 474
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Arteriosclerosis: Aorta

T1236012Hd-4 5 slides
EUR 976
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Artery

T1236013Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Arteriosclerosis: Artery

T1236013Hd-4 5 slides
EUR 976
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Vein

T1236020Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Heart

T1236122Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - hypertension: Kidney

T1236142Hd-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Kidney

T1236142Lup 5 slides
EUR 534
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Asthma: Lung

T1236152Ld-1 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Bronchitis: Lung

T1236152Ld-2 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Emphysema: Lung

T1236152Ld-3 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Pneumonia: Lung

T1236152Ld-4 5 slides
EUR 465
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Ovary

T1236183Lup 5 slides
EUR 611
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Pancreas

T1236188Lup 5 slides
EUR 474
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Lupus: Spleen

T1236246Lup 5 slides
EUR 474
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

mini capillary tubes 1 mm pk/100

EVS1100-TUBE-1.0 ea
EUR 65

mini capillary tubes 1.5 mm pk/100

EVS1100-TUBE-1.5 ea
EUR 65

maxi capillary tubes 1 mm pk/100

EVS1300-TUBE-1.0 ea
EUR 149

EZ-10 Column and collection tube (blue tube, clear ring, clear collection)

SD5005 100, 100UNIT
EUR 74.36

24x0.2ml Tube, accessory for DryBlock?

IPDB-Block-A
EUR 144

12x0.5ml Tube, accessory for DryBlock?

IPDB-Block-B
EUR 144

6x2ml Tube, accessory for DryBlock?

IPDB-Block-C
EUR 144

6x15ml Tube, accessory for DryBlock?

IPDB-Block-E
EUR 264

3x50ml Tube, accessory for DryBlock?

IPDB-Block-F
EUR 264

mini-wide tube gel insert

EVS1200-TUBEINSERT ea
EUR 437

0.65ml Tube, Amber, 1000/Bag

BT613-A 1PK, 1000UNIT
EUR 62.97

0.65ml Tube, Blue, 1000/Bag

BT613-B 1PK, 1000UNIT
EUR 68.4

0.65ml Tube, Green, 1000/Bag

BT613-G 1PK, 1000UNIT
EUR 68.4

0.65ml Tube, Natural, 1000/Bag

BT613-N 1PK, 1000UNIT
EUR 68.4

0.65ml Tube, Natural, Sterile, 1000Tubes

BT613-NS 1PK, 1000UNIT
EUR 72.2

0.65ml Tube, Red, 1000/Bag

BT613-R 1PK, 1000UNIT
EUR 68.4

0.65ml Tube, Yellow, 1000/Bag

BT613-Y 1PK, 1000UNIT
EUR 68.4

2ml Tube, Natural, 1000/Bag

BT619-N 1PK, 1000UNIT
EUR 73.78

2ml Tube, Natural, Sterile, 1000Tubes

BT619-NS 1PK, 1000UNIT
EUR 86.5

1.5ml Tube, Natural, 1000/Bag

BT620-N 1PK, 1000UNIT
EUR 87.8

Mouse Tubulin Epsilon (TUBe) Protein

20-abx069524
  • EUR 704.00
  • EUR 286.00
  • EUR 2165.00
  • EUR 829.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

TUBE ROTOR FOR MINI CENTRIFUGE

6770-RT 1/pk
EUR 67
Description: Lab Equipment; General Purpose Centrifuges (affliated brand)

Tube End Fittings 5/pk

1294005 4unit
EUR 246

1-3 mm Tube Connector

1296106 6unit
EUR 264

2-4 mm Tube Connector

1296107 6unit
EUR 264

3-5 mm Tube Connector

1296108 6unit
EUR 264

Human Tubulin Epsilon (TUBe) Protein

20-abx166876
  • EUR 676.00
  • EUR 286.00
  • EUR 2082.00
  • EUR 801.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

11-Well Centrifuge Tube Box

R011-N 1 UNIT
EUR 51.52

12-Well Centrifuge Tube Box

R012-N 1 UNIT
EUR 52.18

24-Well Centrifuge Tube Box

R024-N 1 UNIT
EUR 52.61

Thus the risk of breast cancer for women heterozygous A-T is not limited to young women, but appears higher in old age. Of all breast cancers in the United States, 6.6% can occur in women who are A-T heterozygotes. This proportion was some great times from the approximate proportion of BRCA1 mutation carriers in breast cancer cases with onset at any age.

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