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Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
The follicular variant of papillary thyroid carcinoma usually presents as a tumor packaged and less common as infiltrative neoplasms partial / non-encapsulated. The shape is packed rarely metastasize to the lymph nodes, whereas infiltrative tumor often harbor nodal metastasis. Profile follicular variant molecules are shown to be close to the group adenoma / carcinoma follicular tumors with high RAS and BRAF mutation rate is very low.
A comprehensive survey of oncogenic mutation in the follicular variant of papillary thyroid carcinoma in accordance with the shape of encapsulated and infiltrative not done. paraffin tissue from 28 patients with packaged and 19 with the follicular variant of infiltrating into the target mass spectrometry genotyping include the most significant oncogenes in thyroid carcinoma: 111 mutations in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, AKT1 and other related genes. There were no differences in age, gender, tumor size and angioinvasion between encapsulation or infiltrative tumor. infiltrative carcinomas have a higher frequency of extrathyroid extension, positive margins and nodal metastases from encapsulated tumor (P <0.05). The BRAF 1799T> A mutation was found in 5 of 19 (26%) of tumor infiltrating and none of the encapsulated carcinoma (P = 0.007).
Instead, RAS mutations were observed in 10 of 28 (36%) of the encapsulated group (5 NRAS_Q61R, 3 HRAS_Q61, 1 HRAS_G13C and 1 KRAS_Q61R) and only 2 of 19 (10%) of the infiltrative tumors (P = 0.09). One carcinoma packed show PAX8 / PPARgamma rearrangements, whereas infiltrative tumor harbored two RET / PTC fusion. Packed follicular variant of papillary thyroid carcinoma had a molecular profile is very close to the follicular adenoma / carcinoma (high level RAS and BRAF mutation). Infiltrative follicular variant had the opposite molecular profile closer to classical papillary thyroid carcinoma than follicular adenoma / carcinoma (BRAF> RAS mutation). Profile molecule is packaged and infiltrative follicular variant align their biological behavior (ie, nodal metastatic and invasive pattern).
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
molecular heterozygous genotype showed ataxia-telangiectasia tend to breast cancer.
Approximately 1.4% of the general population are heterozygous carriers of the gene for ataxiatelangiectasia (A-T), an autosomal recessive progressive neurological syndromes in which cancer incidence homozygotes was about 100 times that of the general population’s level. The hypothesis that A-T heterozygotes tend to breast cancer tested with robust statistical method contains an index-based genotyping test molecule. A-T gene carrier status of 775 blood relatives in the family 99 A-T is determined by tracing the A-T gene in each family through flanking DNA markers closely linked.
There were 33 women with breast cancer that can genotype; 25 of them A-T heterozygotes, compared with the expected (odds ratio 3.8, 95% confidence limits from 1.7 to 8.4, one-sided p = 0.0001) 14.9. This suggests that the gene heterozygous A-T predisposition to breast cancer. For 21-onset breast cancer before age 60, the odds ratio was 2.9 (1.1 to 7.6, p = 0.009) and for 12 cases with onset at age 60 or older, the odds ratio was 6.4 (1 , 4 to 28.8, p = 0.002).
Urogenital Tissue Slide (Fallopian Tube-Benign)
11-903-10um
ProSci
10 um
EUR 241.8
Urogenital Tissue Slide (Fallopian Tube-Benign)
11-903-4um
ProSci
4 um
EUR 216.6
cDNA - Human Adult Normal Tissue: Fallopian Tube
C1234115-10
Biochain
10 reactions
EUR 215
Urogenital Tissue Slide (Fallopian Tube-Abnormal)
11-905-10um
ProSci
10 um
EUR 241.8
Urogenital Tissue Slide (Fallopian Tube-Abnormal)
11-905-4um
ProSci
4 um
EUR 216.6
cDNA - Monkey (Rhesus) Normal Tissue: Fallopian Tube
C1534115
Biochain
40 reactions
EUR 578
Total Protein - Human Adult Normal Tissue: Fallopian Tube
P1234115
Biochain
1 mg
EUR 513
Human Urogenital Tissue Slide (Fallopian Tube normal) (5 slides/pk)
HTS-11901
Alpha Diagnostics
1 pk
EUR 343.2
Human Urogenital Tissue Slide (Fallopian Tube Benign) (5 slides/pk)
HTS-11903
Alpha Diagnostics
1 pk
EUR 343.2
Human Urogenital Tissue Slide (Fallopian Tube Abnormal) (5 slides/pk)
HTS-11905
Alpha Diagnostics
1 pk
EUR 343.2
Control sections for FD NeuroApop™ Kit (frozen)
PCS102-2
FD Neurotechnologies
each
EUR 80.54
Description: Best quality products
Frozen Tissue Section - Asthma: Lung
T1236152Ld-1
Biochain
5 slides
EUR 475
Frozen Tissue Section - Lupus: Ovary
T1236183Lup
Biochain
5 slides
EUR 682
Frozen Tissue Section - Lupus: Kidney
T1236142Lup
Biochain
5 slides
EUR 587
Frozen Tissue Section - Lupus: Spleen
T1236246Lup
Biochain
5 slides
EUR 515
Frozen Tissue Section - Lupus: Adrenal
T1236004Lup
Biochain
5 slides
EUR 515
Frozen Tissue Section - Emphysema: Lung
T1236152Ld-3
Biochain
5 slides
EUR 475
Frozen Tissue Section - Pneumonia: Lung
T1236152Ld-4
Biochain
5 slides
EUR 475
Frozen Tissue Section - Lupus: Pancreas
T1236188Lup
Biochain
5 slides
EUR 515
Frozen Tissue Section - Bronchitis: Lung
T1236152Ld-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Tumor: Bone
T1235023
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Lung
T1235152
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Skin
T1235218
Biochain
5 slides
EUR 330
Frozen Tissue Section - hypertension: Vein
T1236020Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Tumor: Brain
T1235035
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Colon
T1235090
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Liver
T1235149
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Ovary
T1235183
Biochain
5 slides
EUR 330
Frozen Tissue Section - Lupus: Spinal Cord
T1236234Lup
Biochain
5 slides
EUR 515
Frozen Tissue Section - hypertension: Heart
T1236122Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Tumor: Breast
T1235086
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Kidney
T1235142
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Rectum
T1235206
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Testis
T1235260
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Uterus
T1235274
Biochain
5 slides
EUR 330
Frozen Tissue Section - hypertension: Artery
T1236013Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - hypertension: Kidney
T1236142Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Tumor: Adrenal
T1235004
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Bladder
T1235010
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Parotid
T1235190
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Stomach
T1235248
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Thymoma
T1235264
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Thyroid
T1235265
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Lymphoma
T1235161
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Pancreas
T1235188
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Prostate
T1235201
Biochain
5 slides
EUR 330
Frozen Tissue Section - Human Tumor: Esophagus
T1235106
Biochain
5 slides
EUR 330
Frozen Tissue Section - Arteriosclerosis: Aorta
T1236012Hd-4
Biochain
5 slides
EUR 1060
Frozen Tissue Section - Arteriosclerosis: Artery
T1236013Hd-4
Biochain
5 slides
EUR 1060
Frozen Tissue Section - Human Adult Normal: Lung
T1234152
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Skin
T1234218
Biochain
5 slides
EUR 343
Frozen Tissue Section - Alzheimer's Disease: Brain
T1236035Alz
Biochain
5 slides
EUR 475
Frozen Tissue Section - Parkinson's Disease: Brain
T1236035Par
Biochain
5 slides
EUR 475
Frozen Tissue Section - Dementia: Brain: Thalamus
T1236079Dem
Biochain
5 slides
EUR 475
Frozen Tissue Section - Lupus: Heart: Pericardium
T1236133Lup
Biochain
5 slides
EUR 515
Frozen Tissue Section - Pulmonary embolism: Lung
T1236152Ld-5
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Brain
T1234035
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Colon
T1234090
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Heart
T1234122
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Liver
T1234149
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Ovary
T1234183
Biochain
5 slides
EUR 629
Frozen Tissue Section - Human Adult Normal: Penis
T1234194
Biochain
5 slides
EUR 343
Frozen Tissue Section - Arrhythmia, infarct: Heart
T1236122Hd-1
Biochain
5 slides
EUR 475
Frozen Tissue Section - Liver Cirrhosis: Prostate
T1236201Lcs
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Breast
T1234086
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Retina
T1234110
Biochain
5 slides
EUR 529
Frozen Tissue Section - Human Adult Normal: Kidney
T1234142
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Rectum
T1234206
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Spleen
T1234246
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Testis
T1234260
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Throat
T1234263
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Uterus
T1234274
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Vagina
T1234283
Biochain
5 slides
EUR 343
Frozen Tissue Section - Lupus: Blood Vessel: Artery
T1236013Lup
Biochain
5 slides
EUR 515
Frozen Tissue Section - Depression: Brain: Thalamus
T1236079Dep
Biochain
5 slides
EUR 475
Frozen Tissue Section - Liver Cirrhosis: Esophagus
T1236106Lcs
Biochain
5 slides
EUR 475
Frozen Tissue Section - Dementia: Brain: Frontal Lobe
T1236051Dem
Biochain
5 slides
EUR 475
Frozen Tissue Section - Dementia: Brain: Hippocampus
T1236052Dem
Biochain
5 slides
EUR 883
Frozen Tissue Section - Human Adult Normal: Adipose
T1234003
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Adrenal
T1234004
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Bladder
T1234010
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Trachea
T1234160
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Parotid
T1234190
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Stomach
T1234248
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Appendix
T1234006
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Pancreas
T1234188
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Placenta
T1234200
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Prostate
T1234201
Biochain
5 slides
EUR 343
Frozen Tissue Section - Depression: Brain: Frontal Lobe
T1236051Dep
Biochain
5 slides
EUR 475
Frozen Tissue Section - Depression: Brain: Hippocampus
T1236052Dep
Biochain
5 slides
EUR 883
Frozen Tissue Section - Human Adult Normal: Esophagus
T1234106
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Diaphragm
T1234169
Biochain
5 slides
EUR 343
Frozen Tissue Section - Dementia: Brain: Parietal Lobe
T1236066Dem
Biochain
5 slides
EUR 475
Frozen Tissue Section - Alzheimer's Disease: Brain: Pons
T1236071Alz
Biochain
5 slides
EUR 475
Frozen Tissue Section - Parkinson's Disease: Brain: Pons
T1236071Par
Biochain
5 slides
EUR 475
Frozen Tissue Section - Dementia: Brain: Temporal Lobe
T1236078Dem
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Brain: Pons
T1234071
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Lymph Node
T1234161
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Epididymis
T1234105
Biochain
5 slides
EUR 343
Frozen Tissue Section - Dementia: Brain: Occipital Lobe
T1236062Dem
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Spinal Cord
T1234234
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Gallbladder
T1234118
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Parathyroid
T1234189
Biochain
5 slides
EUR 758
Frozen Tissue Section - Depression: Brain: Parietal Lobe
T1236066Dep
Biochain
5 slides
EUR 475
Frozen Tissue Section - Depression: Brain: Temporal Lobe
T1236078Dep
Biochain
5 slides
EUR 475
Frozen Tissue Section - Congenital heart disease: Heart
T1236122Hd-3
Biochain
5 slides
EUR 475
Frozen Tissue Section - Congestive Heart Failure: Heart
T1236122Hd-6
Biochain
5 slides
EUR 794
Frozen Tissue Section - hypertension: Heart Atrium, left
T1236126Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Depression: Brain: Occipital Lobe
T1236062Dep
Biochain
5 slides
EUR 475
Frozen Tissue Section - hypertension: Heart Atrium, right
T1236127Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Multiple Sclerosis Disease: Brain
T1236035Msc
Biochain
5 slides
EUR 475
Frozen Tissue Section - Alzheimer's Disease: Brain: Amygdala
T1236036Alz
Biochain
5 slides
EUR 475
Frozen Tissue Section - Parkinson's Disease: Brain: Amygdala
T1236036Par
Biochain
5 slides
EUR 475
Frozen Tissue Section - Alzheimer's Disease: Brain: Thalamus
T1236079Alz
Biochain
5 slides
EUR 475
Frozen Tissue Section - Parkinson's Disease: Brain: Thalamus
T1236079Par
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Brain: Amygdala
T1234036
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Brain: Midbrain
T1234059
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Brain: Thalamus
T1234079
Biochain
5 slides
EUR 343
Frozen Tissue Section - Alzheimer's Disease: Brain: Pituitary
T1236068Alz
Biochain
5 slides
EUR 883
Frozen Tissue Section - Parkinson's Disease: Brain: Pituitary
T1236068Par
Biochain
5 slides
EUR 883
Frozen Tissue Section - hypertension: Heart Ventricle, left
T1236138Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Ductus Deferens
T1234100
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Skeletal Muscle
T1234171
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Small Intestine
T1234226
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Diabetic Diseased Tissue: Eye
T1236108Dia
Biochain
5 slides
EUR 662
Frozen Tissue Section - Alzheimer's Disease: Brain: Cerebellum
T1236039Alz
Biochain
5 slides
EUR 475
Frozen Tissue Section - Parkinson's Disease: Brain: Cerebellum
T1236039Par
Biochain
5 slides
EUR 475
Frozen Tissue Section - hypertension: Heart Ventricle, right
T1236139Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Brain: Brain Stem
T1234075
Biochain
5 slides
EUR 343
Frozen Tissue Section - Alzheimer's Disease: Brain: Frontal Lobe
T1236051Alz
Biochain
5 slides
EUR 475
Frozen Tissue Section - Parkinson's Disease: Brain: Frontal Lobe
T1236051Par
Biochain
5 slides
EUR 475
Frozen Tissue Section - hypertension: Interventricular Septum
T1236130Hd-2
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Adult Normal: Brain: Cerebellum
T1234039
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Diabetic Diseased Tissue: Lung
T1236152Dia
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Diabetic Diseased Tissue: Skin
T1236218Dia
Biochain
5 slides
EUR 475
Frozen Tissue Section - Alzheimer's Disease: Brain: Hippocampus
T1236052Alz
Biochain
5 slides
EUR 883
Frozen Tissue Section - Human Adult Normal: Brain: Frontal Lobe
T1234051
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Blood Vessel: Vein
T1234020
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Brain: Optic Nerve
T1234064
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Heart: Atrium (left)
T1234126
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Adult Normal: Brain: Hippocampus
T1234052
Biochain
5 slides
EUR 758
Frozen Tissue Section - Human Adult Normal: Heart: Pericardium
T1234133
Biochain
5 slides
EUR 343
Frozen Tissue Section - Human Diabetic Diseased Tissue: Brain
T1236035Dia
Biochain
5 slides
EUR 475
Frozen Tissue Section - Human Diabetic Diseased Tissue: Colon
T1236090Dia
Biochain
5 slides
EUR 475
Thus the risk of breast cancer for women heterozygous A-T is not limited to young women, but appears higher in old age. Of all breast cancers in the United States, 6.6% can occur in women who are A-T heterozygotes. This proportion was some great times from the approximate proportion of BRCA1 mutation carriers in breast cancer cases with onset at any age.