Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

The follicular variant of papillary thyroid carcinoma usually presents as a tumor packaged and less common as infiltrative neoplasms partial / non-encapsulated. The shape is packed rarely metastasize to the lymph nodes, whereas infiltrative tumor often harbor nodal metastasis. Profile follicular variant molecules are shown to be close to the group adenoma / carcinoma follicular tumors with high RAS and BRAF mutation rate is very low.

A comprehensive survey of oncogenic mutation in the follicular variant of papillary thyroid carcinoma in accordance with the shape of encapsulated and infiltrative not done. paraffin tissue from 28 patients with packaged and 19 with the follicular variant of infiltrating into the target mass spectrometry genotyping include the most significant oncogenes in thyroid carcinoma: 111 mutations in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, AKT1 and other related genes. There were no differences in age, gender, tumor size and angioinvasion between encapsulation or infiltrative tumor. infiltrative carcinomas have a higher frequency of extrathyroid extension, positive margins and nodal metastases from encapsulated tumor (P <0.05). The BRAF 1799T> A mutation was found in 5 of 19 (26%) of tumor infiltrating and none of the encapsulated carcinoma (P = 0.007).

Instead, RAS mutations were observed in 10 of 28 (36%) of the encapsulated group (5 NRAS_Q61R, 3 HRAS_Q61, 1 HRAS_G13C and 1 KRAS_Q61R) and only 2 of 19 (10%) of the infiltrative tumors (P = 0.09). One carcinoma packed show PAX8 / PPARgamma rearrangements, whereas infiltrative tumor harbored two RET / PTC fusion. Packed follicular variant of papillary thyroid carcinoma had a molecular profile is very close to the follicular adenoma / carcinoma (high level RAS and BRAF mutation). Infiltrative follicular variant had the opposite molecular profile closer to classical papillary thyroid carcinoma than follicular adenoma / carcinoma (BRAF> RAS mutation). Profile molecule is packaged and infiltrative follicular variant align their biological behavior (ie, nodal metastatic and invasive pattern).

Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.

molecular heterozygous genotype showed ataxia-telangiectasia tend to breast cancer.

Approximately 1.4% of the general population are heterozygous carriers of the gene for ataxiatelangiectasia (A-T), an autosomal recessive progressive neurological syndromes in which cancer incidence homozygotes was about 100 times that of the general population’s level. The hypothesis that A-T heterozygotes tend to breast cancer tested with robust statistical method contains an index-based genotyping test molecule. A-T gene carrier status of 775 blood relatives in the family 99 A-T is determined by tracing the A-T gene in each family through flanking DNA markers closely linked.

There were 33 women with breast cancer that can genotype; 25 of them A-T heterozygotes, compared with the expected (odds ratio 3.8, 95% confidence limits from 1.7 to 8.4, one-sided p = 0.0001) 14.9. This suggests that the gene heterozygous A-T predisposition to breast cancer. For 21-onset breast cancer before age 60, the odds ratio was 2.9 (1.1 to 7.6, p = 0.009) and for 12 cases with onset at age 60 or older, the odds ratio was 6.4 (1 , 4 to 28.8, p = 0.002).

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cDNA - Human Adult Normal Tissue: Fallopian Tube

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Control sections for FD NeuroApop™ Kit (frozen)

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Frozen Tissue Section - Asthma: Lung

T1236152Ld-1 5 slides
EUR 475

Frozen Tissue Section - Lupus: Ovary

T1236183Lup 5 slides
EUR 682

Frozen Tissue Section - Lupus: Kidney

T1236142Lup 5 slides
EUR 587

Frozen Tissue Section - Lupus: Spleen

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Frozen Tissue Section - Lupus: Adrenal

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Frozen Tissue Section - hypertension: Heart

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Frozen Tissue Section - Human Tumor: Breast

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Frozen Tissue Section - Human Tumor: Kidney

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Frozen Tissue Section - Human Tumor: Rectum

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Frozen Tissue Section - Human Tumor: Testis

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Frozen Tissue Section - Human Tumor: Uterus

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Frozen Tissue Section - hypertension: Artery

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Frozen Tissue Section - hypertension: Kidney

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Frozen Tissue Section - Human Tumor: Adrenal

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Frozen Tissue Section - Human Tumor: Bladder

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Frozen Tissue Section - Human Tumor: Parotid

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Frozen Tissue Section - Human Tumor: Stomach

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Frozen Tissue Section - Human Tumor: Thymoma

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Frozen Tissue Section - Human Tumor: Thyroid

T1235265 5 slides
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Frozen Tissue Section - Human Tumor: Lymphoma

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Frozen Tissue Section - Human Tumor: Pancreas

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Frozen Tissue Section - Human Tumor: Prostate

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Frozen Tissue Section - Human Tumor: Esophagus

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EUR 1060

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Frozen Tissue Section - Human Adult Normal: Lung

T1234152 5 slides
EUR 343

Frozen Tissue Section - Human Adult Normal: Skin

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Frozen Tissue Section - Alzheimer's Disease: Brain

T1236035Alz 5 slides
EUR 475

Frozen Tissue Section - Parkinson's Disease: Brain

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T1236133Lup 5 slides
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T1236152Ld-5 5 slides
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Frozen Tissue Section - Human Adult Normal: Brain

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Frozen Tissue Section - Human Adult Normal: Colon

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Frozen Tissue Section - Human Adult Normal: Heart

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Frozen Tissue Section - Human Adult Normal: Liver

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Frozen Tissue Section - Human Adult Normal: Ovary

T1234183 5 slides
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Frozen Tissue Section - Human Adult Normal: Penis

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Frozen Tissue Section - Arrhythmia, infarct: Heart

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Frozen Tissue Section - Liver Cirrhosis: Prostate

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Frozen Tissue Section - Human Adult Normal: Breast

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Frozen Tissue Section - Human Adult Normal: Throat

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Frozen Tissue Section - Human Adult Normal: Uterus

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Frozen Tissue Section - Human Adult Normal: Vagina

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Frozen Tissue Section - Lupus: Blood Vessel: Artery

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T1234003 5 slides
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T1234190 5 slides
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Frozen Tissue Section - Human Adult Normal: Stomach

T1234248 5 slides
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Frozen Tissue Section - Human Adult Normal: Appendix

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Frozen Tissue Section - Human Adult Normal: Pancreas

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Frozen Tissue Section - Human Adult Normal: Esophagus

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T1234059 5 slides
EUR 343

Frozen Tissue Section - Human Adult Normal: Brain: Thalamus

T1234079 5 slides
EUR 343

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T1236068Alz 5 slides
EUR 883

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EUR 883

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T1236138Hd-2 5 slides
EUR 475

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T1234100 5 slides
EUR 343

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T1234171 5 slides
EUR 343

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EUR 343

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EUR 662

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EUR 475

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EUR 475

Frozen Tissue Section - hypertension: Heart Ventricle, right

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EUR 475

Frozen Tissue Section - Human Adult Normal: Brain: Brain Stem

T1234075 5 slides
EUR 343

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EUR 475

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EUR 475

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EUR 343

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EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Skin

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EUR 883

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EUR 343

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EUR 343

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EUR 343

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EUR 343

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EUR 758

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EUR 343

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EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Colon

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Thus the risk of breast cancer for women heterozygous A-T is not limited to young women, but appears higher in old age. Of all breast cancers in the United States, 6.6% can occur in women who are A-T heterozygotes. This proportion was some great times from the approximate proportion of BRCA1 mutation carriers in breast cancer cases with onset at any age.

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